I misunderstood the home defense part, so here is attempt #2: an AR10 will punch holes through multiple walls before stopping, it is far from ideal in home defense. If you live alone and no one else for miles, sure; if not, consider something with less over-penetration danger.
Next, shooting a magnifying scope with both eyes open is no problem, but it doesn't work like a 1X or red dot, where both eyes process a single image.
If you need true 1X, a 1-6X would be my choice. If you want a bit more on the top, you'll have to give up a bit on the bottom for a 3-9.
I have a few rifles with offset red dots. I get your "pointless on large caliber rifles" but the red dot is about speed and "precision" rather than the round being fired. I have a 16"barrelled AR10, it is relatively quick handling and it wears a red dot for when the 2.5-10X is too much. At 20 yards with a fast-moving target, any magnification is too much.
For what you state as primary need, I would do a 3-9 with an offset red dot, a decent one is small, unobtrusive, and not nearly as pricey as they once were. I've had good luck with the Burris fastfire series, I think mine are all 2s and 3s. They have a decent battery life, they hold zero, and dot brightness has a memory feature in at least the series 3, coming back where it was at the last cycle. Mine have been reliable in every way.
If you don't like that setup, a good 1-6X would work also, so long as it is a true - or very near - 1X at the bottom. The SS is very good, I hear, and I run a Vortex HD2 1-6 and would be fine putting that on an AR10. It is heavy, but sight picture is awesome and the gun isn't light enough to throw anything "off".
The plural of "anecdote" is not "data."